Beta Catenin
Alias/Synonym: Intercellular Junctions, Wnt Signal Transduction Pathway
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- B-catenin is normally present at the cell surface, bound to E-cadherin surface protein, participating in cell-cell structures. It is also involved in the Wnt signal transduction pathway. Abnormalities in B-catenin lead to nuclear and/or cytoplasmic accumulation of the protein, which may be seen in tumors such as fibromatosis, several sarcomas, and polyps in patients with familial adenomatous polyposis.
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A