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Alias/Synonym: Intercellular Junctions, Wnt Signal Transduction Pathway
CPT Code: 88342
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
Sample Quantity, Minimum:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
No liquid specimens.
B-catenin is normally present at the cell surface, bound to E-cadherin surface protein, participating in cell-cell structures. It is also involved in the Wnt signal transduction pathway. Abnormalities in B-catenin lead to nuclear and/or cytoplasmic accumulation of the protein, which may be seen in tumors such as fibromatosis, several sarcomas, and polyps in patients with familial adenomatous polyposis.