BCL-2

Alias/Synonym: B-cell Subset, Follicular Lymphoma

CPT Code: 88342

Includes:

Specimen Type, Preferred:

Formalin fixed paraffin embedded tissue

Specimen Type, Alternate:

Sample Quantity, Preferred:

1 block

2 slides

Sample Quantity, Minimum:

N/A

Transport Container:

Paraffin block

Unstained slides

Transport Temperature:

Room temperature

Collection Instructions:

Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.

Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.

Specimen Stability:

N/A

Rejection Criteria:

No liquid specimens.

Uncharged slides

Clinical Significance:

BCL-2 is an inner mitochondrial membrane protein that appears to inhibit apoptosis in a wide variety of tissues. In lymphomas (follicular, some DLBCL) with certain translocations, Bcl-2 is upregulated, although immunohistochemical expression may be identified in the absence of the translocation. The protein is normally expressed in small B lymphocytes of the mantle and marginal zones, as well as many T lymphocytes. The antibody may also be useful in the differential diagnosis of soft tissue neoplasms.

Limitations:

Turnaround Time:

1 day(s)

Reference Ranges:

N/A

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