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Arginase 1

Alias/Synonym: Urea Cycle Enzyme in Liver

CPT Code: 88342

Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
Arginase-1 (ARG-1) is a key enzyme of the urea cycle found in liver that catalyzes the conversion of L-arginine into L-ornithine and urea. ARG-1 is a highly specific and sensitive marker of benign liver and hepatocellular carcinoma (HCC) and is useful in the distinction of primary vs. metastatic hepatic tumors. ARG-1 is quite specific for hepatocellular carcinoma, but has also shown some staining in cholangiocarcinoma.
Turnaround Time:
1 day(s)
Reference Ranges: