Arginase 1
Alias/Synonym: Urea Cycle Enzyme in Liver
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- Arginase-1 (ARG-1) is a key enzyme of the urea cycle found in liver that catalyzes the conversion of L-arginine into L-ornithine and urea. ARG-1 is a highly specific and sensitive marker of benign liver and hepatocellular carcinoma (HCC) and is useful in the distinction of primary vs. metastatic hepatic tumors. ARG-1 is quite specific for hepatocellular carcinoma, but has also shown some staining in cholangiocarcinoma.
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A