ABL1 Kinase Domain
Alias/Synonym: ABL1
CPT Code: 81170
- Includes:
- Specimen Type, Preferred:
- Bone marrow aspirate
- Specimen Type, Alternate:
- Peripheral blood
- Sample Quantity, Preferred:
- 2mL
- Sample Quantity, Minimum:
- 0.5mL
- Transport Container:
- Lavender top (EDTA) tube
- Green top (Sodium Heparin) tube
- Transport Temperature:
- Refrigerated
- Collection Instructions:
- If bone marrow is dry tap, submit 5-10mL peripheral blood.
- Specimen Stability:
- Room temperature: 2 day(s)
- Refrigerated: 3 day(s)
- Rejection Criteria:
- Room temperature
- Clotted
- Frozen
- Clinical Significance:
- Detection of mutations that correlate to resistance to kinase inhibitors in patients with Chronic Myeloid Leukemia (CML) and acute lymphoblastic leukemia with Philadelphia chromosomes.
- Limitations:
- This test is designed to detect only mutations within the ABL kinase domain.
- Turnaround Time:
- 5-7 day(s)
- Reference Ranges:
- 5%